These idiots also assume that everything he's been doing hasn't prevented the symptoms of worse outcomes from this condition, for all we know if he didn't go full biohacker he would be completely fucked by this disorder but actually gave himself a fighting chance.
"The most severe risk of a parent receiving blood from their child is TA-GVHD, a rare but highly fatal immune condition.The Mechanism: Your child inherits half of their Human Leukocyte Antigens (HLA) from you. Because of this partial genetic match, your immune system may fail to recognize your child’s white blood cells as foreign invaders.The Attack: The child's white blood cells survive, replicate, and aggressively attack your body's organs and tissues, treating your body as foreign."
TA- GVHD is universally fatal , brian does not have TA-GVHD . He has an autoimmune disorder , not an alloimmune disorder .
And , because we know TA-GVHD is a possibility , banks (here, the doctors) will irradiate the blood components of the donor blood thereby deactivating the T-lymphocytes present in them
Blood transfusions can trigger or exacerbate autoimmune diseases in susceptible individuals. The process—known as transfusion-related immunomodulation—alters your immune system. The introduction of foreign donor cells can cause immune confusion, potentially leading to the development of autoimmune conditions. Transfused blood can also, exacerbate underlying rheumatic or autoimmune conditions
He has had these symptoms for over 20 years, his venture into longevity does not go that far back. He just recently got a formal diagnosis. Its possible his protocol made it difficult to diagnose because he was otherwise extremely healthy
Also, one of the reasons why people become these weird biohackers is because they have some underlying condition. They are hypersensitive to the tiniest thing that they do wrong because it makes them sick, and they end up believing certain things they do have value to everybody when it only affects them (ex: avoiding a food you have allergy to is great for you, but does nothing for the majority of people who don’t have that allergy).
Yeah you see a lot of unproven science in chronic illness spaces. Some of it hasn't been scientifically proven to work yet but works anecdotally, but others have been extensively researched and had no provable effects. But the problem is when you're waved away by doctors or told that nothing can be done you have to take matters into your own hands to be able to make life bearable.
He had another autoimmune condition prior to this one, and they tend to cluster. This is not crazy news to chronically ill people and I wouldn't be surprised if his insane routines and health monitoring meant that he avoided a lot of the symptoms. My high sodium diet helped mitigate the worst of my POTS symptoms before I knew what was going on. My IBS cleared up a lot when I found out I couldn't have meat or dairy. I knew something was wrong and when I changed things about my diet and habits things got worse or better. Doctors have largely been unhelpful until recently.
This right here. I have chronic illness going back most my life. Doctors don’t have answers. I ended up developing severe cfs/me and fibromyalgia. But also have connective tissue issues causing widespread injuries. I believe in science, but applied medicine isn’t always scientific, or has its limits for a variety of reasons. I’ve started trying peptides, and other alternatives not because I’m ignorant or am doing some weird looksmaxxing, but because I’m running out of options.
I’ve had friends ask what they should try, and I say “if everything’s fine, there’s no reason to start injecting yourself with unapproved chemicals from a Chinese lab.”
This was my thought when I saw the documentary about him. I immediately wondered if he had an underlying unidentified illness that was somatically driving him to want to “perfect” his health.
He may have given himself this disorder with the amount of obsessing he does over his health. Chronic stress is a major trigger for developing autoimmune conditions.
He might have also triggered it with the amount of interventions he has done, such as 6 monthly plasma transfusions, getting his blood "cleaned" via machine and reinjected (potentially with added microplastics), hair transplants, hair dye, cosmetic procedures, etc. If you are already susceptible to autoimmune issues, doing things like that can trigger something.
I have a few different autoimmune disorders, and have had hodgkin lymphoma as well (also autoimmune-linked, occurs in reaction to being exposed to EBV, which 98% of the population is exposed to yet has little to no reaction to).
I am very familiar with autoimmune conditions and how even things that seem small or no biggie to others can trigger them. Your body can take any inflammation - like from a cut, or sunburn, etc - and run with it, triggering an episode.
Chronic stress is one of the biggest factors influencing the development of autoimmune conditions.
The silence on the topic is enough of an answer to know, we can all discount their words on this topic, which is the point of someone pushing back against nonsense.
It's also possible that consuming over 100 tablets a day completely fucked his stomach... it wouldn't surprise me if banging as many supplements and vitamins into himself as possible didn't also have some side effects.
Yeah, people on here say he consults with doctors. There is no doctor worth their degree that will recommend you take 100+ supplements daily. Most people with decent diets will have zero deficiencies in vitamins and minerals.
Well, is there a study that shows that taking all 40 provide benefits and there are no side effects from consuming that many compounds a day (not withstanding all the other chemicals they are mixed with, contained in etc)?
No, so, in the name of the experiment that is Bryan Johnson, it's perfectly possible that his experiment with pharmacologically active compounds has side effects: almost all of them do. Sure I'm speculating, but so is anyone who says that it's completely innocent.
They only have benefits if you are deficient in those nutrients. Otherwise, you piss out the extra. Very few people living in the first world are actually deficient in nutrients barring a few typical cases or folks with actual health problems. Also, your chart doesn't talk about benefits. It list what those things do in your body. If you already have those nutrients, more isn't better and is often time detrimental.
All of which is fixed with one simple multivitamin, or better yet, a good diet. Not 40 separate supplements. You will also notice I mentioned a few typical cases so you just regurgitated what I already knew. My problem with this guy isn't what he is trying to do, it's his anti science way of doing it. Suppose he does live a long time. Which supplement did it? You would never know because this is an uncontrolled experiment with hundreds of confounding variables on an N=1 population. Any results would be completely ignored by the scientific community. If he wants results, he should spend his money on actual research using the scientific method. He is a billionaire tech bro who was good at one thing and is deluded into thinking he is the best at everything and is desperatly dumping his body full of a bunch of stuff that could even cause harm in the wrong amounts.
Much of them aren’t common nutrients or nutrients at all (some are drugs, others are uncommon things like cocoa flavanols), and the ones that are nutrients commonly found in food may be close to impossible to work into his specialized (vegan) diet. Each of these supplements were found to or are strongly suspected to help with longevity and health, and he’s taken many ineffective or counterproductive ones out of his stack.
You can view the stack here (I believe the list in this article is accurate)
Look, I'm not saying that each alone isn't beneficial. What i doubt is that taking 40 little pills, all mixed with all kinds of other compounds, and which all also INTERACT with each other when they're in your body, is completely innocent.
I find it bonkers how many people are defending this guy: the whole point it is an experiment, and any one who knows even the FIRST thing about medical science knows that all compounds have side effects; especially when you make cocktails out of them.
I stand corrected, but how many pills is he consuming everyday?
Either way, it's a crazy amount. Just the stuff that is used to mix these things is not well studied when it's consumed at such a high amount, so regularly, over such long periods. It would be nuts if it didn't have some kind of side effects. These pills are not pure, and even if they have been scientifically tested they have not been tested in combination.
There are so, so, so many drugs, vitamins, and nutrients that you do NOT take together because of how they interact. This guy is - yes - experimenting. Experimenting does not automatically mean he is going to live for a long time; most experiments fail. The guy may have inadvertently fucked up his stomach - what is so controversial about that statement?
You don't think the billionaire with some of the best private doctors on the planet hasnt thought of any of the things you have? That they wouldn't use the most pure organic forms of supplements without random chemical binders? You're being ignorant and think somehow these obvious factors wouldn't be considered when they decide what he takes. It's laughable actually how much of an armchair expert you're being lol
Man - the guy is EXPERIMENTING! What is with all these folks that assume because someone's a billionaire they can't also get things wrong?
You know all those folks paying billions to cryogenically store their bodies? It's an experiment - sci-fi - it's built out of speculation. I'm not claiming to be an expert; far from it - but just because some guy has got money doesn't mean he suddenly becomes an exception to what it means to EXPERIMENT.
You don't know the results in advance! Even if they go for the 'purest' drugs, even if he gets all of his pharmaceuticals made in-house, that still doesn't mean that what he is doing is supported by current research, because it hasn't been done before: it's an experiment; negative side effects wouldn't be surprising. They'd be likely
I find it so so bizarre how many people are on here defending some guy just because he's rich!
Sure, but an N=1 experiment with no controls and this many things being tested at once is completely useless for scientific purposes. You can learn absolutely zero from his "experiments". He would be better served investing his money into actual medical science.
“There is no doctor… who would recommend” Did he specifically say they recommend the 40 supplements he takes? Or is he taking 40 supplements and also working with doctors who basically have to work with what they’ve got? Yea they’re probably not recommending it, but they can’t exactly stop him and they’re still gonna consult with him
Please show me the doctor and the tests that they ran that shows he is short on 100+ nutrients and needs to use that many supplements. Then show me the research that that doctor used to support that opinion. You will be looking for a while because there is no such research supporting this.
Go ask the doctors bud, youll have to do your one research instead of whining at me. Niether of us are educated on the topic no matter how much you pretend.
My wife is a doctor, can confirm, she said this guy is a nut who likely only hired doctors who agreed with his ideas, or he did this against their advice. She works with zero doctors and said, "even starving kids in Africa are unlikely to need 100 supplements per day."
So just to be clear, you said to ask doctors. I asked a doctor, she said you were wrong. Now you’re telling me that her opinion is anecdotal, but that his doctor’s opinions (that we don’t know) are not anecdotal. Fascinating.
I don't need to do the research because I didn't make the claim that 100+ supplements a day was good for me. The onus is on the person making the claim and since you were supporting that claim, you need to provide the evidence or I would be right to dismiss it. I don't take "he consulted a doctor, trust me bro" as evidence. Also, many dead celebrities have consulted their doctors too. Doctors can be bought.
I'm sorry, I've spent the last four years studying prescribing cascades: there is no doctor in their right mind who would recommend taking over 100 pills a day. It's just nuts. Maybe it's good, maybe it isn't: the whole point is it's an experiment, no? It's called polypharmacy, and it's a very very well known issue around prescribing both medications as well as supplements, if you're taking more than 10 different pharmacologically active compounds you're in the danger zone. So no, I'm not making stuff up.
I for one welcome our new billionaire vampire overlords.
We've tried trickle down economics with money and it didn't work, obviously that is because money is only liquid when Scrooge McDuck dives into it or someone is trying to confuse you when talking about their personal finances.
Blood however, is a much better standard than gold! Now we have a real shot at finally getting trickle down running efficiently.
Neither of us know what caused it. As you point out, there are some autoimmune diseases that are triggered by our behavior and some that are entirely genetic.
You hold this guy in perfect regard such that if he lived to 110 it would be due to all of his experiments. But if he suddenly gets ill its all due to random chance. I get that it breaks the dream that benevolent billionaires will solve all our problems. But there's a very real chance that there are health effects of all his biohacking.
I looked it up and got the feeling that he has caused this with his strange diet.
"The gut microbiome might also play a role in autoimmune gastritis.
According to Kellie Blake RDN, LD, IFNCP, a registered dietitian specializing in functional nutrition, an unbalanced gut microbiome contributes to increased intestinal permeability (leaky gut) and inflammation. Research has shown a connection between a leaky gut and some autoimmune diseases like autoimmune gastritis."
"Supplements and Liquids: Dozens of "Longevity Actives" mixed into his food or taken as pills, alongside decaf coffee blended with macadamia nut milk."
for all we know if he didn't go full biohacker he would be completely fucked by this disorder but actually gave himself a fighting chance.
Not likely. It is autoimmune so either it was genetic or something he was injecting into himself has caused his immune system to start attacking a part of his body
We should be able to tag users so we can filter them in the future. Ie. you tag someone "idiot" and you can toggle "idiots" off in your reddit experience
Yes, and that's a huge part of the problem: while he tests more experimental therapies that may be costly to do full-blown studies on, the personal data he presents is all anecdotal.
Similarly, many of the longevity studies or therapies are on long time scales, he bounces around different therapies every few months, it seems, based on immediate changes to biomarkeers.
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u/Original_Location_21 Jul 06 '26
These idiots also assume that everything he's been doing hasn't prevented the symptoms of worse outcomes from this condition, for all we know if he didn't go full biohacker he would be completely fucked by this disorder but actually gave himself a fighting chance.