r/Cholesterol • • 3d ago

General Statin side effects

Started Rosuvastatin(10mg) and baby aspirin (81mg) and have problematic side effects. I have preexisting conditions (severe insomnia) and (severe constipation) and one or both drugs have made the constipation unmanageable. Started statin shopping and from what I can see every statin effects one or both of those conditions. I'm at a loss here. Both preexisting conditions I can barely keep in check prior to the statin. I can't afford to have either one effected and I can't afford to have a heart attack. Thought, suggestions, recommendations?

4 Upvotes

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u/Ok_Huckleberry6820 3d ago

I did not have the constipation when I was taking Simvastatin, but it was a problem when I was switched to Rosuvastatin. So the side effect might be less with another statin. For me, psyllium husk in water, one chewable Miralax a day helps, and also a teaspoon of olive oil in the morning.

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u/Narrow-Angle-5583 3d ago

Appreciate the reply. From my research thus far every statin I've found either causes constipation or insomnia. I'm hoping someone here knows of one that causes neither. Fingers crossed.

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u/Koshkaboo 3d ago

You are ignoring everyone, apparently including your doctor, who tells you that you are taking too much psyllium. Statins causing constipation is at best a very uncommon side effect. The excess psyllium is more likely. If you can get statin working you won’t need to supplement psyllium.

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u/Narrow-Angle-5583 2d ago

You clearly can't comprehend what the alternative is. Days without a bowel movement and when I finally do go I will spare you the details of the horror show. My digestive system is dysfunctional. The only one that can help with that is a gastroenterologist. I've been on the waiting list for months. Also worth mentioning is bearing down during constipation cause me heart pain and can easily trigger a heart event. I keep my system moving or else.

https://www.hindustantimes.com/lifestyle/health/heart-attack-in-the-bathroom-why-straining-while-passing-stool-can-be-dangerous-a-cardiologist-explains-101788597673853.html

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u/Next_Programmer_3305 3d ago

I had severe insomnia and constipation due to magnesium deficiency.

10 Signs You Are Magnesium Deficient https://www.nutritionwarehouse.com.au/a/fittalk/supplements/10-signs-you-are-magnesium-deficient

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u/Narrow-Angle-5583 3d ago

Appreciate the recommendation. I already take 400mg magnesium citrate at night for insomnia.

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u/Next_Programmer_3305 3d ago

Okay. Try this simple home test out to see if you have enough stomach acid. It's a decent test too. I have low stomach acid due to autoimmune gastritis and didn't burp for 15 minutes. I take betaine HCL with pepsin supplements with meals. Game changer!

https://youtube.com/shorts/5ovdddMQaic?si=2ExkBf1M0WuHKIIi

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u/Narrow-Angle-5583 3d ago

Appreciate the helpful comment, I'm going to give it a try.

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u/Next_Programmer_3305 3d ago

Okay šŸ‘ It's a potential cause of your symptoms.

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u/Narrow-Angle-5583 2d ago

27 minutes, no burp, no nothing.

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u/Next_Programmer_3305 2d ago edited 2d ago

Ooh wow we found your issue! Hypochlorhydria! Now you have to figure out why! And it could be multiple causes too.

I've actually had two reasons causing the combination of elevated cholesterol and low stomach acid - Hashimoto's thyroiditis and years later high levels of toxic mould in my house. In my case, existing low stomach acid levels from autoimmune gastritis worsened both times. Cholesterol levels back to normal when sorting out both health issues.

https://my.clevelandclinic.org/health/diseases/23392-hypochlorhydria

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u/Narrow-Angle-5583 1d ago

This definitely tracks! I suppose it will take a Dr to officially make a diagnosis but this makes a lot of sense. I appreciate you making the effort, thanks. It was about an hour and 15 minutes before I finally burped.

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u/Next_Programmer_3305 1d ago edited 1d ago

Wow that's a long time! I tried this test years ago. I really should try this test again. My acid levels are lower now. This year I accidentally ran out of my betaine HCL with pepsin supplements and hello SIBO. It took like 6 to 7 weeks to get rid of SIBO after I was restarted my supplement again! Dr Berg has a good video on this. You need stomach acid to kill off bacteria! I already eat intermittent fasting style and have for decades so that's interesting how it helps.

Small Intestinal Bacterial Overgrowth(SIBO) Steals Your Nutrients https://youtu.be/fOIjbB27enE?si=HQs5syFVxYWu0OXJ

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u/Narrow-Angle-5583 1d ago

Ya I was pretty surprised myself. The more I think about it the more sense this makes. I often spot undigested, intact vegetables when I inspect my bowel movement. Vegetables should be incredibly easy to digest yet there they are. Thanks again, it's not easy being my own Dr. I might never have figured this out without your help.

I love Dr. Berg. Thorough, easy to understand explanations and interesting, relevant topics. He really is an asset.

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u/keepgoing66 3d ago

psyllium husk, and stay hydrated. Literally one dose of psyllium (e.g. a tablespoon mixed with 8 oz liquid) can make a difference. And, it helps lower LDL even more.

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u/Iudicrouspopinjay 3d ago

Just be careful with the psyllium. I read it can be tough on the digestive system to suddenly increase fiber, and I have a sensitive gastrointestinal system so when I started taking it I began with a very small amount. I started with one quarter teaspoon in the morning and I increase 1/4tsp every couple of days and am currently up to 1.25tsp in the morning and 1.25tsp in the evening. I plan to stop when I get to 2tsp twice a day.

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u/HotRevenue3944 3d ago

A serving of psyllium husk is a teaspoon, not a tablespoon. Overdoing it and with insufficient liquid taken with the husk can lead to a literal intestinal blockage and visit to the ER. And, it needs to be titrated, i.e. start with 1/8 tsp, and work your way up to a dose that works for your body (for me, that is 1/2 tsp; more than that, and it creates problems).

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u/keepgoing66 2d ago

I have no problems with a tablespoon of psyllium husk powder. I don't use the husk form. Many people here take that much and more. Perhaps your body has a poor tolerance for it.

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u/Narrow-Angle-5583 3d ago

Prior to the medication I was already up to 1/2 cup of psyllium husk a day as well as 1/2 cup of chia seeds per day with 3L water and 4 sennocote despite my doctor saying that's too much and I was still constipated. At this point my digestive system has stopped all together.

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u/HotRevenue3944 3d ago

You are literally wrecking your digestive system with that much fiber, OP. You’re constipated because of it. And your body is speaking to you by pausing your digestion.

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u/Narrow-Angle-5583 2d ago

I have to keep my system moving or face the consequences. This is the lesser of two evils so to speak.

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u/Turbulent_Plum_4643 2d ago

There are other ways to deal with constipation besides these really really too high levels of fiber. Folks are right that you should rethink the plan. An rousuvastatin hasnt affected poop or my sleep.

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u/Narrow-Angle-5583 2d ago

What are the other ways? I'm glad you haven't experienced any side effects. Since humans are bio-diverse everyone is effected differently.

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u/see_blue 3d ago

Massive fiber consumption can also lead to constipation.

Those amounts would plug me up or give me a lot of gas and poop bombs.

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u/Narrow-Angle-5583 2d ago

This is the only thing that works.

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u/meh312059 Quality ContributoršŸ«€ 3d ago

That amount of psyllium might be dangerous. Psyllium is constipating if over-consumed.

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u/Narrow-Angle-5583 2d ago

It's the only thing that works. It's either that or not going at all.

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u/meh312059 Quality ContributoršŸ«€ 2d ago

You may have to reset your GI tract. That'll take several weeks to months. How much fiber are you getting from non-psyllium sources such as fruit, legumes, sweet potatoes, oatmeal, hulled barley etc? I'd cut back the psyllium and layer those other options in.

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u/Narrow-Angle-5583 2d ago

It depends on the day. I've tried different approaches. At one point it was a lot. I was eating steamed broccoli and rice with kidney beans twice a day and still constipated. The Dr. said I needed to add soluble fiber so that's what I did. I started small with no results and added until I got to a place that worked.

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u/meh312059 Quality ContributoršŸ«€ 2d ago

It can take several months. You might need to start small with the soluble from real food (10g) and work up from there.

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u/Narrow-Angle-5583 2d ago

The problem is I'm stuck where I'm at. I will spare you the gory details of what happens after a couple of days of not going. One other significant concern is the risk of a cardiac event on the toilet from bearing down. I have a referral to a GI specialist but the waiting list is very long.

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u/meh312059 Quality ContributoršŸ«€ 2d ago

I hope you are able to find relief and a solution soon!

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u/Narrow-Angle-5583 2d ago

Appreciate the sentiment. Unfortunately all I can do is chose the lesser of two evils at this point. Better days ahead....

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u/keepgoing66 3d ago

Have you seen a licensed dietician? Maybe it would help to take a step back and start fresh with a diet. FODMAP diet? It must be so frustrating.

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u/Narrow-Angle-5583 3d ago

Unfortunately I haven't because I can't afford it but since my diagnosis I have switched to a very low saturated fats diet which is mostly veggies and grains with very little meat. It hasn't helped. I've been on a waiting list to see a gastroenterology for months and I have no idea when I may be getting an appointment.

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u/keepgoing66 3d ago

When my wife was having various digestive issues, the dietician put her on a FODMAP diet, as well as suggesting a probiotic. I'm no doctor, and a hundred different things can be wrong, but one of the simplest causes is a food allergy. My wife has things that trigger digestive problems: chocolate, garlic, too much fiber. FODMAP starts with a simple low-fiber diet, and puts a bunch of things on the no-go list. Some fruits and veggies are good, others are not. Dairy can be problematic. Anyway, you can look it up and decide if you want to give it a try. Even a week's time is enough to see progress if it really does apply to you.

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u/Narrow-Angle-5583 3d ago

Appreciate you following up. Can't hurt to try. I'll try anything at this point.

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u/keepgoing66 2d ago

Stop taking the psyllium and fhe chia seeds. Completely. It's too much fiber.

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u/Therinicus Quality ContributoršŸ«€ 1d ago

Insomnia is awful. I feel for you.

I’ve had luck with a low dose of L theanin, gaba, and melatonin.

Suku makes something in a sugar free gummy but you can just buy them individually too.

I really hope you get through it

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u/Narrow-Angle-5583 1d ago

Ya it's hell on earth. I've managed to get a decent grip on it if I jump thru a dozen hoops relating to sleep hygiene ect. Great suggestion. I take a mix of gaba L theanine and magnesium with reasonable results. I used to take melatonin as well but I discovered a number of reasons to cease taking it. Appreciate you comment. :)

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u/[deleted] 3d ago

[deleted]

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u/Narrow-Angle-5583 3d ago

I do pretty much all f that already. There is an underlying issue that I assume can only be addressed by a Gastroenterologist.

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u/meh312059 Quality ContributoršŸ«€ 3d ago

Please contact your doctor and ask about tweaking your dose of rosuva, switching to atorva (minimum dose), adding zetia, or other non-statin agents. You have some options!

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u/Narrow-Angle-5583 2d ago

I've done so already. Unfortunately he's very unresponsive so I have no idea when I will hear back from him.

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u/meh312059 Quality ContributoršŸ«€ 2d ago

You might need to switch doctors or get a referral to cardiology for a more personalized approach. Be sure to ask for a preventive cardiologist as they are more knowledgable about how to tweak medications etc.

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u/Zambrotta2026 2d ago

Also ich hab Rosuvastatin, Atorvastatin und Lovastatin eingenommen und bei allen dreien hab ich schwere Verstopfung und Schlafstƶrungen bekommen. Nach dem Absetzen der Staine sind diese Nebenwirkungen alle wieder komplett verschwunden. Nun versuche ich an den PSCk9 - Hemmer Leqvio heran zukommen.

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u/Narrow-Angle-5583 2d ago

Danke, dass du dich dazu geäußert hast. Das ist wirklich frustrierend. Ich hoffe, du bekommst den Zugriff hin und es klappt bei dir.