r/ScienceUncensored • u/costoaway1 • 12d ago
This common vitamin could help fight one of the deadliest brain cancers
https://sciencedaily.com/releases/2026/10/261001095423.htmEdward (Ed) Waldner knew something was wrong, even though he could not explain exactly what was happening. At age 55, he was constantly exhausted, regardless of how demanding his day had been. At first, he wondered whether sleep apnea might be responsible.
Then he began noticing changes in the way he walked. His heels would sometimes drag, and his movement no longer felt normal. When his symptoms became especially concerning one day, he went to the Emergency Department.
"The doctor said I had a mass on my brain and needed to see an oncologist," says Waldner.
The mass turned out to be glioblastoma, an aggressive form of brain cancer that is notoriously difficult to treat. Standard care typically combines surgery, radiation, and chemotherapy. Surgeons try to remove as much of the tumor as possible, but glioblastoma cells can spread into surrounding brain tissue, making complete removal extremely difficult. Even after treatment, the cancer commonly returns.
Researchers at the University of Calgary are now investigating whether an unexpected addition to standard treatment could help: high doses of vitamin B3, also known as niacin.
Waldner was invited to participate in the clinical trial.
"I have no problem trying to help anybody. I agreed. I want to help myself too," says Waldner. "I can tell you being part of this research helps me mentally because we're trying. When I left the hospital after surgery I was told, that's it, that's all we can do."
The study is being led by two researchers who are members of both the Hotchkiss Brain Institute and Arnie Charbonneau Cancer Institute. Gloria Roldan Urgoiti, MD, is an oncologist who specializes in brain cancers, while Wee Yong, PhD, is a neuroscientist who studies how the immune system affects the brain.
Their research centers on a key problem with glioblastoma: the tumor can interfere with the immune system, weakening the very cells that might otherwise help attack the cancer.
The team designed the study to determine whether niacin could restore some of those impaired immune cells and help them destroy tumor cells.
The idea first emerged from experiments in Yong's laboratory using mice. Those studies found that niacin treatment extended survival, encouraging the researchers to move the approach into a combined Phase I and Phase II clinical trial in people.
Phase I trials generally focus heavily on safety and determining an appropriate dose, while Phase II studies begin looking more closely for signs that a treatment may provide a clinical benefit.
"Normally the immune system will try to counter and prevent tumor growth, however, this brain cancer supresses the immune system," says Yong, a professor at the Cumming School of Medicine (CSM). "Niacin treatment rejuvenates immune cells so they can do what they are supposed to do, attack and kill the cancer cells. I see it as an ongoing 'battle for the brain'."
For the current trial, researchers are studying controlled release niacin given alongside recommended chemotherapy and radiotherapy. One goal is to establish the highest dose that can be used safely. Another is to look for evidence that adding niacin may improve how long patients remain alive without their cancer getting worse.
That measure is known as progression-free survival.
Before beginning the study, researchers established a threshold for continuing the trial. They planned to stop if progression free survival at six months failed to improve by at least 20 percent compared with older studies.
Early results from 24 patients surpassed that threshold. At six months, 82 percent of participants had not experienced progression of their cancer. According to the researchers, that represents a 28 percent increase compared with previous studies.
The team describes the early findings as promising for a cancer that remains incurable, but the results are still preliminary and involve a relatively small group of patients.
"Glioblastoma is the most aggressive brain cancer in adults. Survival of patients with this condition hasn't changed significantly for 20-years," says Roldan Urgoiti, a clinical associate professor at the CSM. "Anything that may help should be explored, but it requires strict protocols and safety monitoring."
The findings were published in the *Journal of Neuro-Oncology*.
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u/JuicySpark 12d ago
Way too long didn't read. Give me a dumbed down version.
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u/YuppiesEverywhere 12d ago
Seem too dumb already. No vitamin can fix you
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u/costoaway1 12d ago
This is the theory of mind that has prevented true research. Our cells and bodies are built upon them as their foundation…of course vitamins can steer disease outcome.
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u/trafozsatsfm 10d ago
Niacin. Although phase 1 of the study will need to be carried out repeatedly over a prolonged period.
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u/pruchel 12d ago
"Although niacin is a vitamin, the researchers emphasize that high doses should not be viewed as harmless simply because the substance is widely available.
Large amounts of vitamins such as niacin can be toxic and may cause harmful effects if they are taken without appropriate medical oversight. The doses and treatment used in the clinical trial are being carefully controlled and monitored by medical professionals."
How exactly? Unless you already have some sort of liver disease or some sort of issue with low bp it simply isn't dangerous at all as far as I know. Just stay away from any kind of extended release/nicotinamide variant and take pure nicotinic acid. We routinely used 3-6+ grams a day before the statin era.
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u/JuicySpark 9d ago
You mean I cant down a bottle of niacin to help me fight cancer ? Luckily I read this
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u/TrinityCindy 7d ago
I recall a documentary that had this exact information.
The doctor was a director in Texas who studied gilboblastoma tumors and b3.
He had major successes and in the end the Texas board and big pharma took his license and a very young girl died after she was forced to be treated with chemotherapy and radiation.
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u/Space19723103 6d ago
any article beginning "this one thing [fixes] cancer" is going to be terrible reporting if not outright fraudulent
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u/costoaway1 6d ago
“The study is being led by two researchers who are members of both the Hotchkiss Brain Institute and Arnie Charbonneau Cancer Institute. Gloria Roldan Urgoiti, MD, is an oncologist who specializes in brain cancers, while Wee Yong, PhD, is a neuroscientist who studies how the immune system affects the brain.”
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u/PlainSpader 12d ago
Ever take Niacin? It’s one of the most uncomfirtable feelings because all your blood rushes to the surface of your skin making it red and you feel like you’re on fire. But that’s way better than…
Also, if you need to pass a pee test.