r/interesting • u/Adventurous_Most_558 • 5h ago
SCIENCE & TECH Japan is trialing a drua that rearows human teeth by blocking USAG-1-a protein that keeps dormant tooth buds switched off. Phase 1 is done. Phase lla in children with congenital tooth loss is next. If it works, dentures and implants could become obsolete.
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u/Craic-Den 5h ago
I've heard about this for years, when do these trials end and go into commercialisation? Or is this just investor snake oil.
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u/Artemis_SpawnOfZeus 4h ago
By 2030 it should be available for congenital tooth loss (people born missing teeth)
Whether it will make dentures obsolete is complicated.
Congenital tooth loss means your jawbones are still shaoed to accept teeth. But if you lose a tooth later in life, your bones heal over the socket, meaning there isnt really a spot for the tooth to go.
It might work, but would probably need surgical intervention as well. Probably wont see the drug available for non-congenital tooth loss until at least 2040.
Also, its not going to make dentures "obsolete" its causing a preexisting tooth bud (all humans [and most mammals] have a vesitigial third set of tooth buds) to grow, if you fuck up those teeth, youd still need dentures.
It only buys you one more shot at having teeth in the most idealized scenario.
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u/Fuzzy_Inevitable9748 4h ago
Man having a third set of teeth would be awesome though, especially if you could just recruit the specific tooth you need.
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u/Important_Variety_85 4h ago
I’d take a 3rd set along with my adult teeth and have rows like a shark
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u/Fuzzy_Inevitable9748 2h ago
I don’t know how much I would like having my mouth full of teeth, imagine the food that would get stuck in there
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u/Artemis_SpawnOfZeus 4h ago
The drug does grow the buds one at a time. So you would be able to pick and choose the teeth needed.
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u/Artemis_SpawnOfZeus 4h ago
I would like to state that i am very much in the camp of "this drug is awesome"
Its just not a dental panacea
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u/Borkydog 5h ago
Ah, here we go again, this is just not true. And the news about this trials are misleading as hell. No, you would not be able to regrow teeth by 2030 or by 2035 and even if you could in future it would be very limited
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u/Comfortable_Spot4262 5h ago
trial
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u/Artemis_SpawnOfZeus 4h ago
For congenital tooth loss it seems really promising. For noncongential tooth loss more research is definitely needed.
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u/Wtf_lolz123 5h ago
I remember when we would shame posts for spelling. wtf happened.
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u/Bostonterrierpug 4h ago
Many people regard the use of what they consider correct English usage as a sign of intelligence— an attitude with no basis in fact.
-Deborah Tannen
Furthermore, cognitive rigidity correlates with lower IQ.
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u/Wtf_lolz123 4h ago
Damn, okay. Wasn’t claiming I’m smarter or better.
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u/CoverCommercial3576 4h ago
can you please correct your post. you misspelled a ton of stuff. if makes no sense.
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u/Exalted-Stork-1308 4h ago
We've already read that Phase II was over and 78% of the patients grew new teeth. So please, OP, either do a more thorough research on the subject of gtfo
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u/CivicCryptid 55m ago
Knowing my luck I would take this and a tooth would grow out of my fucking eyeball
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u/phillyfanatic1776 5h ago
Ya, well we renamed a lake!
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u/Vrajitorul_din_Orz 5h ago
What a time to be alive! Trial or not it's insane we are even trying this. But my question is: how the doctors will lobby againts this since the implant industry is worth 6 billions.
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u/Artemis_SpawnOfZeus 4h ago
It wont eliminate implants. Currently its only being tested for congenital tooth loss. Even under the best scenario, its only going to make one more set of teeth. If you lose set 3 youd still need implants or dentures.
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