For context. I recently got diagnosed with what I think is Guttate Psoriasis.my Derm only told me I have psoriasis after a biopsy, but didn’t specify what kind. I did my own research and came to find all the different types, I didn’t even know there were different types! He wanted to put me on Cosentyx right away after seeing my flare. This flare started back on April of 2026, I think what triggered it was my constant stress and drinking… like heavy drinking. Idk my family Hx, so not sure if it runs in the family. It started as one dime size scale patch in my mid (L) ABD, then progressed to my legs and all throughout my back, my scalp for sure is horrible. Doing research on Cosentyx, I learned it’s a biologic, suppresses your immune system, that made me skeptical since I work in the medical field, around sick people all the time. I went to my PCP and she recommended Otezla. Honestly it worked wonders, like no more flares on my skin besides a few patches on my elbow and knees, my scalp cleared for a bit but recently started to flare with the dry weather. I love Otezla honestly! But the side effects are horrible; constant mood swings is a major one, I have CPTSD, depression and anxiety which I’m medicated for, but being on otezla makes me literally wanna die and have some majors depressive episodes. Along with nausea and loss of appetite, I’ve lost 20 pounds since I’ve been on it. I’ve been on it for three months, in the beginning the side effects were horrible, but after a month they subsided. I recently went through a job / insurance change and was out of it for two weeks, started back up a week ago, and man and I feeling these depressive, nausea, loss of appetite side effects. I know everyone is different, but any recommendations on psoriasis meds? Like idk what to do, this is a horrible diseases that took my confidence and I just wanna feel like myself again. ATM I’m going through a depressive episode and now numb, like idc about anything ordeal.

I was prescribed rinvoq “15 dose” months ago and it was working fine, then all of a sudden it stopped working. I am now on 30 dosage and it hasn’t started clearing back up. It’s actually getting worse still. Has anyone else dealt with this problem?

Does anyone have any tips for applying zoryve foam to scalp without making hair super greasy? I was prescribed this once a while ago and wasn’t compliant because of this issue. I know it sounds silly, but I don’t need to wash my hair daily, so it just became burdensome. BUT my scalp psoriasis is out of control and I’m losing my mind and my derm wants me to give this another try. If anyone has any success and has suggestions, that would be greatly appreciated. Thank you!!

I’ve had psoriasis since my teens, initially mostly on my scalp, but it worsened around age 19 and began affecting my groin and anal areas, along with swaths of my stomach and back. I’ve tried several biologics: Taltz cleared most areas but not my genitals, Ilumya worked best overall but didn’t completely resolve the genital symptoms. While on Ilumya it was relatively controlled as long as I put eucrisa on twice a day, but I was still restricted in a lot of what I did (pre planning showers, not being able to sweat freely, occasional discomfort). I decided to try Bimzelx, but after a few months, I started having discomfort even with eucrisa.

After months of trying different things through my Colorectal and my derm, eventually it got so bad I was in the ER from the pain. I tried a new derm (several, actually) and they pinged the issue as being a fungal infection. I took fluconazole and an anti bacterial, which dramatically improved my symptoms. I then got a biopsy, while temporarily being off Bimzelyx (now restarted after a 3 month break) and it came back as showing…eczema? But the doctors still suspect psoriasis (a second opinion biopsy said dermatitis). I’ve been using zoryve and hydrocortisone once a day, and when I went in, hey! Doctor said I look completely clear.

The problem is, I still have a ton of discomfort. She’s referring me now to a GI, a urologist, and a psoriasis specialist she knows.

My main symptoms are persistent raw, itchy, burning/chafing discomfort around the anus, groin creases, and scrotum. The worst location seems to shift: for a while it was mainly around my anus, but recently the scrotal skin and groin creases have been bothering me most. The scrotum can look somewhat red, particularly on the right side, but the redness comes and goes, and the skin can look relatively normal even when it feels uncomfortable. Heat, sweating, walking, and physical activity tend to aggravate things; cooling down and getting dry can help. I’ve also occasionally experienced sudden prickling/electric-jolt sensations around the groin, thigh creases, and perineal/anal area. My dermatologist recently said the skin looked completely clear and didn’t show steroid-induced thinning, but I’m still experiencing significant discomfort. I’ve wondered about residual skin sensitivity, nerve issues, ongoing dermatitis or fungal infection, or something internal.

Tl; DR. My skin is clear, but I still have symptoms. Biologic said eczema but derm thinks psoriasis. My skin is mostly clear but I still have symptoms. Going to a GI and urologist now, but this stuff is very confusing.

I had my first ever flare up a month ago, at first it was just red spots over my body and just kept spreading everywhere, no itch at first, then the plaque appeared and my god they are painful and itchy, they are constantly shedding, my face is a mess and actually hurts bad with the dry patches and scales, my scalp is also sore with dry patches, I would say at least 90% of my body is covered with no signs of improvement yet, I am after some good body moisturiser and something to wash my skin, hoping this is just a one off thing and will go after a few months.

I had the worse experience with psoriasis during pregnancy and postpartum. Zorvye helped me a ton and now we're planning to conceive againp and derm told me it's not safe for pregnancy and I have to stop the cream. I'm scared to the core that the flares will come back. Any inputs?

(Feel free to tell me if you relate or don't relate to what I'm feeling, and why)
I don't even know how to explain what I've been feeling lately. I think I'm just tired, emotionally more than anything.
Psoriasis has been weighing on me so much recently. It's not just about having patches on my skin or dealing with the physical discomfort. It's the way it makes me feel about myself, the way it affects my thoughts, and how easily something as simple as looking at my skin can ruin my entire mood.
I'm tired of having to think about my skin all the time. I'm tired of worrying about whether it's going to get worse, where the next flare might appear, and how much of my life it's going to affect. I hate how something I have no control over can take up so much space in my mind.
But honestly, the hardest part is what it makes me feel about my future.
Sometimes I think about love and relationships, and I get this horrible feeling in my chest. I wonder if someone could genuinely love me and still accept my psoriasis. (Keep in mind that I live in a society where psoriasis is being looked at in a very negative point of view, and this is scientifically proved unfortunately) I wonder if someone would hesitate to touch me, feel uncomfortable seeing my skin, or look at me differently after finding out I have this condition.
Living in a society where appearance and marriage can carry so much weight makes these thoughts even harder to ignore. I worry that something I never chose and cannot simply get rid of could make it harder for someone to accept me.
And I hate that psoriasis has made me question things that shouldn't even be questions. Whether I'll be desirable. Whether someone will find me beautiful. Whether I'll be able to feel completely comfortable in my own skin around another person without worrying about what they might think.
I know psoriasis isn't contagious. I know it's a medical condition, not something shameful. I know all the logical things I'm supposed to remind myself of. But knowing these things doesn't automatically stop me from feeling insecure or being afraid of how other people might react.
Lately, I've been feeling this emptiness that I can't really explain. It's like I'm grieving something, even though I don't know exactly what. Maybe it's the feeling of not being able to live in my body without constantly thinking about it. Maybe it's the fear of what the future holds. Maybe I'm just exhausted from carrying all these thoughts around.
And sometimes I feel guilty for being this upset about a skin condition. I tell myself that there are worse things people go through, and that I should be grateful for what I have. But I don't think gratitude and sadness are mutually exclusive. I can appreciate my life and still struggle with something that genuinely hurts me.
I don't want psoriasis to define me, but sometimes it feels like it's affecting the way I see myself more than I want to admit. I wish I could just exist without thinking about my skin, without worrying about someone noticing it, and without wondering whether it will affect my chances of being loved.
I don't really know what I need to hear. I guess I just want to talk to people who understand what it's like to deal with the emotional side of this condition, especially the loneliness, the insecurity, and the fear that it might affect your relationships.
I'm tired of constantly thinking about my skin. I'm tired of worrying about whether it's going to get worse, whether new areas will be affected, and how much more of my life this condition will take over. Even when I'm trying to focus on something else, it's always somewhere in the back of my mind. A flare up isn't just a change in your skin. It can affect your entire mood, your confidence, your daily routine, and your ability to feel at peace with yourself.

On Medicare and the price of Temfya is ridiculous. Anyway to get it cheaper?

Please, someone help me 😭 I’m having the worst sebopsoriasis flare-up. Last October, I had the same flare-up, so I visited a dermatologist who prescribed me a bunch of medications. They worked, and my skin stayed clear for around 3–4 months after that. I stopped using them, and during the summer, I started experiencing flare-ups again, but they weren’t that bad. My scalp would only get itchy when it became sweaty, and my face wasn’t as dry, although the redness was still there.

In September, I visited another dermatologist who prescribed itraconazole and methylprednisolone aceponate for my face. My skin cleared up completely, and everyone was complimenting it, but as soon as I stopped using the medication, the flare-up came back 😭 Now, my face is as bad as it was last October, and my scalp also has dry, red patches.

It’s driving me nuts!

Tried steroids, feels like when I come off it comes back worse every time.

Tried tar, the smell just is too awful.

Lastly I’ve tried only topical vitamin D, which helps, but is messy (we only get the ointment here in Norway, not the solution).

I’ll be continuing using the vit D salve, but anyone has any other helpful tips or tricks?

The itching is just so bad, I am aware of my scalp most of the day. The shedding is awful and I feel so unhygenic.

Thanks for reading:)

Hey just wondering if anyone on here is in the Kootenays and how their condition has been the last few weeks? I used my regular steroid gel but I went full out for a couple days, putting it all over after a shower for two days in a row because I had a trip coming up. It cleared but then came back really strong and now I am suffering. I read that this happens and I should have just stuck to using smaller amounts of the gel 😣 anyway then I wondered if the climate this time of year is also getting any others. Seems to be really dry and starting to get chilly.
Let me know what your experience has been if you’re in this area!

hi all, I've been doing weekly MTX shots (+ folic acid) since July and nothing's really happened. my sores are still there and I'm seeing new ones. and my liver values are up in my blood tests (I admit I didn't quit alcohol 100%). Anyways, I'm off the booz now and kinda seeing if it's worth continuing. I'm up for another 3 months til done. But I don't see progress, and I have more and more small patches in back and arms. it sucks. anyone else here who did this? thanks

I had scalp psoriasis for many years but I have an embarrassing problem that has never happened before. It feels like underneath the skin there are large solid scales, the only way I can describe them is like lose plastic? Idk, I’m going insane. I’m not about to peel my scalp skin to get rid of the scales, but I don’t know how to treat this. I have bethametazone + vit b on the mail and my derm is working on getting a new biologic for me. What is happening.

This post is about my partner, not myself. I’ve seen him struggle with psoriasis for the past decade, he’s tried many treatments and diets, but all with little to no improvement, some treatments help a little better than others, like light therapy, but it requires a lot of effort going to the clinic weekly and doing the bulb thing at home for an hour each day, so the energy to keep up with those treatments faded over time, and it seems like he is just done with it all and gave up now.

I know he’s struggling, he’s in pain and embarrassed, there’s not a piece of skin not affected at this point. It seems like it’s not even flare-ups anymore, it’s a constant state of massive patches. I want to help him but I cant get him enthusiastic about seeing a doctor again. He’s treatment-burned-out Is there anything, in your experience, that helped in a minimal invasive way? I’m sure things have developed over the past ten years, perhaps there’s more out there that he might be up for trying.

(He definitely doesn’t want steroid crème again because he’d have to soak his whole body, and iffy about that much steroids)

Thank you!

My doctor prescribed the Halox one for my scalp while the HBSALIC for the rest of my body.

I checked the label and everything.. it's totally same..

Can soembody please give me a reason to why my dermat gave me two of the same thing. I've been wondering the same for a while.

Alphosyl was the only thing that worked for me and I was fortunate enough to have stocked up before it was discontinued, but I’ve spent the last 2 years trying g everything I can with no success. None of the other coal tar products work, the topical steroid from my GP doesn’t work.

Has anyone else who found Alphosyl was the holy grail product managed to find a solution?

Or another autoimmune disease? I know these bitches cluster.

Hi!

Please recommend psoriasis-friendly foundation or powder to cover redness and bumps.

I have oily skin and I live in a tropical country.

Thank you!

Anyone here on Tirzepatide/Zepbound and had psoriasis flares? Has the GLP1 made a difference on your psoriasis? I have psoriasis on my fingers also, but my scalp is what’s going crazy right now. I’m 6 months in/54 pounds down on Tirzepatide and having a psoriasis flare. My scalp is going nuts. I woke up in the middle of the last night and covered my scalp in Clobetasol because I couldn’t sleep for the intense itching. I know GLP1s are supposed to make it better but for me I think the weight loss and GLP1 have actually made it worse. I will gladly accept any suggestions.

Thought this was interesting and possibly of some use for anyone looking for something else to try. This is a AI (Gemini) summary but it's a pretty good summary of things:

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Glutathione shows promise as an emerging, supportive option for managing psoriasis, but it is not currently established as a standalone cure or standard primary treatment. Clinical research indicates that individuals with psoriasis typically exhibit significantly depleted levels of glutathione and high systemic oxidative stress. Because glutathione acts as the body's "master antioxidant," correcting this deficiency helps calm the systemic inflammation and rapid skin cell turnover characteristic of the disease. [1, 2, 3]

The Medical Link Between Glutathione and Psoriasis

Psoriasis is a chronic autoimmune condition driven by accelerated skin cell proliferation. Under normal conditions, skin cells mature and shed over a month; in psoriatic tissue, this happens in mere days. [1, 2]

• Oxidative Stress Driver: An imbalance between free radicals and the body's antioxidant defenses shifts the body's "redox" balance, signaling skin cells to replicate abnormally fast. [1, 2]
• Deficiency Cycle: Studies published in journals like Frontiers in Medicine show that low baseline glutathione directly correlates with a spike in psoriatic inflammation. When glutathione levels are depleted, the immune system lacks the necessary brakes to temper inflammatory flare-ups. [1, 2]

Current Clinical Evidence

While wide-scale, longitudinal clinical trials are still limited, small pilot studies and clinical case reports have shown encouraging results:

• Oral Glutathione-Enhancers: In a prospective pilot study published in the Journal of Clinical and Aesthetic Dermatology, patients with psoriasis vulgaris were given 20 grams of nondenatured bioactive whey protein isolate daily (which supplies the building blocks to boost cellular glutathione). Over three months, patients demonstrated measurable clinical improvements in their Psoriasis Area and Severity Index (PASI) scores, whether they used the supplement as a standalone or alongside topical therapies and UVB light therapy. [1, 2, 3]
• Intravenous (IV) Glutathione: Case reports have tracked rapid improvements using IV glutathione. A clinical case study of a patient with severe scalp psoriasis noted a 40% to 50% reduction in lesions, scaling, and itching within two weeks of initiating high-dose IV glutathione. However, the study also noted that symptoms relapsed after three months without maintenance dosing, highlighting that it manages rather than cures the underlying pathology. [1]
• Prescription Pathways: The established psoriasis medication Dimethyl fumarate (DMF) operates heavily within this pathway. It interacts with glutathione-S transferase and modulates the Nrf2 transcription factor to reduce keratinocyte hyperproliferation and systemic inflammation. [1, 2]

Delivery Methods and Bioavailability

Standard oral glutathione tablets are notorious for poor absorption, as digestive enzymes break the molecule down before it reaches the bloodstream. If you look to integrate glutathione, alternative administration routes are usually favored by practitioners:

• Liposomal Glutathione: Formulations that encapsulate glutathione in a lipid layer protect it through the digestive tract. Clinical data suggests liposomal delivery can increase bioavailability significantly over standard tablets.
• Precursor Supplementation: Taking precursors like N-acetylcysteine (NAC), L-cysteine, or specialized whey protein isolates allows your liver to synthesize its own glutathione internally.
• Dietary Support: Consuming sulfur-rich and antioxidant-heavy foods like avocado, asparagus, and spinach helps support the body's natural antioxidant synthesis. [1, 2, 3]

Always consult your dermatologist or primary healthcare provider before introducing high-dose glutathione or its precursors into your regimen, especially if you are currently using systemic immunosuppressants or biological therapies for psoriasis.

This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes.

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Probably the most accessible and effective way for most people to increase glutathione levels is to use what the summary calls "precursor supplementation" by supplementing "GlyNAC" which is glycine and NAC (N-acetylcysteine). The glycine is relatively harmless and of little risk but using the NAC in high doses (as usually required to increase glutathione levels to significant levels) has some risks and potential side effects, particularly gastrointestinal.

Note: in normal (no conditions such as psoriasis) humans there is usually very little benefit in increasing glutathione levels in someone under 40 or 50 years old. It's unknown if it might help someone much younger with chronic inflammatory conditions such as psoriasis.

Also a lot is unknown with this. For instance what happens if you take GlyNAC for a year or two and then stop? Can the body rebound back to normal levels of Glutathione or are you basically stuck having to take it for the rest of your life where stopping it makes things even worse than they were before you started?

"The Role of Glutathione-S Transferase in Psoriasis and Associated Comorbidities and the Effect of Dimethyl Fumarate in This Pathway"
https://pmc.ncbi.nlm.nih.gov/articles/PMC8863102/

Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study

https://pmc.ncbi.nlm.nih.gov/articles/PMC3805302/

https://www.healthline.com/health/glutathione-benefits