New preclinical study finds Urolithin A activates a protective pathway in intestinal cells, including in tissue from IBD patients

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https://www.sciencedaily.com/releases/2026/09/260916232529.htm

A recent preclinical study uncovers Urolithin A's potential to improve gut health. Researchers from the University of Louisville found that Urolithin A activates a protective pathway in intestinal cells. In inflammatory bowel disease, triggering certain cellular pathways can cause more inflammation; however, in preclinical models, Urolithin A activated a specific pathway with a beneficial response. This activation strengthened the intestinal barrier, boosted production of protective mucus, and reinforced antimicrobial defenses. The researchers state it's the first study showing how a postbiotic can work with the body's own response systems, helping regulate complex processes that happen during intestinal injury.